Molecular Mechanisms Linking Adiponectin Receptor Signalling and Cancer
نویسندگان
چکیده
Adiponectin is an adipose tissue-derived hormone. It is a key hormone that is responsible for insulin sensitization, and its circulating level is inversely associated with abdominal obesity. Recent studies have shown that a reduced plasma adiponectin level is significantly correlated with the risk of various kinds of cancers. Adiponectin may influence the cancer risk by modulating the metabolic environment indirectly. However several cancer cells express adiponectin receptors, suggesting that adiponectin also may modulate the cancer progression directly. Herein, we review the recent evidence concerning the molecular mechanisms linking adiponectin receptor signaling and cancer. Further studies are required to fully elucidate the molecular mechanisms of the adiponectin-mediated signaling pathway in cancer.
منابع مشابه
Inhibition of Interleukin-1 Receptor-Associated Kinases 1/4, Increases Gene Expression and Serum Level of Adiponectin in Mouse Model of Insulin Resistance
Insulin resistance is a feature of most patients with type 2 diabetes mellitus. Epidemiological evidence suggests a correlation between inflammation and insulin resistant states such as obesity, but the underlying mechanisms are largely unknown. Interleukin-1 receptor-associated kinases (IRAK) play a central role in inflammatory responses by regulating the expression of various inflammatory gen...
متن کاملAdiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis.
Adiponectin is protective against hepatic fibrosis, whereas leptin promotes fibrosis. In HSCs (hepatic stellate cells), leptin signals via a JAK2 (Janus kinase 2)/STAT3 (signal transducer and activator of transcription 3) pathway, producing effects that enhance ECM (extracellular matrix) deposition. SOCS-3 (suppressor of cytokine signalling-3) and PTP1B (protein tyrosine phosphatase 1B) are bot...
متن کاملارتباط پلی مورفیسم گیرنده ی 1 آدیپونکتین 2275738 rs با سرطان روده ی بزرگ
Introduction & Objective: Adiponectin exerts anti-tumor effect through connection to its receptor. Some studies have shown that polymorphism in Adipor1 results in insulin resistance, diabetic type 2 and colorectal cancer (CRC). The purpose of this study is to investigate the incidence mutant allele of adiponectin receptor 1 polymorphism rs2275738 and to examine the association of genetic vari...
متن کاملDirect role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans.
Low adiponectin levels are an independent risk factor for and mediate the effect of obesity on endometrial cancer in epidemiology studies. The direct or indirect mechanisms underlying these findings remain to be elucidated. We first examined the expression of adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) in normal human endometrium and in endometrial cancer tissues ex vivo. We then used KLE ...
متن کاملP-68: Adipkines Play Major Roles in Sperm Motility and Function in Ram
Background: Adipose tissue is not only an energy storage tissue but also an important endocrine organ that secretes protein hormones. Among them, the production and secretion of adiponectin is inversely correlated to the severity of obesity. In adipose tissue, adiponectin production is transcriptionally regulated by peroxisome proliferator-activated receptor-γ (PPAR-γ). Obesity is a major healt...
متن کامل